Platelet-rich fibrin（PRF）：a second-generation platelet concentrate. Part IV：Clinical effects on tissue healing.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e56-60.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology Volume 101, Issue 3, March 2006, Pages e56–e60
Source
Pain Clinic Center, Nice, France.
http://www.sciencedirect.com/science/article/pii/S1079210405005895
Abstract
Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this fourth article, investigation is made into the previously evaluated biology of PRF with the first established clinical results, to determine the potential fields of application for this biomaterial. The reasoning is structured around 4 fundamental events of cicatrization, namely, Angiogenesis, Immune control, Circulating stem cells trapping, and Wound-covering epithelialization. All of the known clinical applications of PRF highlight an accelerated tissue cicatrization due to the development of effective Neovascularization, accelerated wound Closing with fast cicatricial tissue Remodelling, and nearly total Absence of infectious events. This initial research therefore makes it possible to plan several future PRF applications, including plastic and bone surgery, provided that the real effects are evaluated both impartially and rigorously.
Fig. 1. Tooth extraction and osseous filling in a case of terminal periodontitis of wide sites (A and B) are delicate interventions because of the difficulty in obtaining soft tissue coverage on the surface of the osseous injury. Sockets are filled with Phoenix allogenic bone (TBF, France), (C). The use of PRF as cover membranes (D and E) permits a rapid epithelialization of the surface of the site, neutralizing the infectious phenomena. Forty-eight hours postoperative, wound is totally closed and sutures are removed (F).
Fig. 2. During massive cystic ablation of the maxillary (A and B), residual cavity is filled with PRF (C). Two and a half months later, the osseous defect is replaced by a dense and cortical bone (D) instead of the average 10 months naturally. The use of PRF allows acceleration of the physiologic phenomena.
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