Platelet-poor plasma(PPP)
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Platelet-Poor Plasma(PPP)is blood plasma with very low number of platelets(< 10 X 103/μL).
Traditionally, PPP was recommended for use in platelet aggregation studies to both adjust the Platelet-rich plasma concentration, and to serve as a control.
PPP may have elevated levels of Fibrinogen, which has the ability to be form a fibrin rich clot once activated. Wound healing requires cell migration and attachment, which is facilitated by this fibrin clot.
Current Uses
Fibrin sealants have found use in many clinical situations such as blood management, orthopaedic surgery, and cosmetic surgery.
Future possibilities
As a by-product of PRP preparation, PPP may also find use in tissue engineering applications as an Autologous degradable scaffold. This plasma portion is frequently discarded when used with PRP treatments.