A randomized, controlled comparative study of the Wrinkle reduction benefits of a cosmetic Niacinamide/Peptide/Retinyl propionate product regimen vs. a prescription 0·02% Tretinoin product regimen
J.J.J. Fu1, G.G. Hillebrand2, P. Raleigh2, J. Li2, M.J. Marmor2, V. Bertucci3, P.E. Grimes4, S.H. Mandy5, M.I. Perez6, S.H. Weinkle7, J.R. Kaczvinsky2
Article first published online : 8 AUG 2009
DOI: 10.1111/j.1365-2133.2009.09436.x
© 2010 The Authors. Journal Compilation
© 2010 British Association of Dermatologists
British Journal of Dermatology
Volume 162, Issue 3, pages 647–654, March 2010
（http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2009.09436.x/abstract）
Conflicts of interest J.J.J.F., V.B., P.E.G., S.H.M., M.I.P. and S.H.W. are all paid consultants to Procter & Gamble. G.G.H., P.S.R., J.L., M.J.M. and J.R.K. are all employed by Procter & Gamble. This study was funded by Procter & Gamble Beauty, Cincinnati, OH, U.S.A.
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
Keywords :
anti-ageing; niacinamide; retinyl propionate; skin care; tretinoin; wrinkles
Abstract
Summary Background
Tretinoin is considered the benchmark prescription topical therapy for improving fine facial wrinkles, but skin tolerance issues can affect patient compliance. In contrast, cosmetic antiwrinkle products are well tolerated but are generally presumed to be less efficacious than tretinoin.
Objectives
To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription regimen with 0·02% tretinoin for improving the appearance of facial wrinkles.
Methods
An 8-week, randomized, parallel-group study was conducted in 196 women with moderate to moderately severe periorbital wrinkles. Following 2 weeks washout, subjects on the cosmetic regimen (n = 99) used a sun protection factor (SPF) 30 moisturizing lotion containing 5% Niacinamide, Peptides and Antioxidants, a moisturizing cream containing niacinamide and peptides, and a targeted wrinkle product containing niacinamide, peptides and 0·3% retinyl propionate. Subjects on the prescription regimen (n = 97) used 0·02% tretinoin plus moisturizing SPF 30 sunscreen. Subject cohorts (n = 25) continued treatment for an additional 16 weeks. Changes in facial wrinkling were assessed by both expert grading and image analysis of digital images of subjects’ faces and by self-assessment questionnaire. Product tolerance was assessed via clinical erythema and dryness grading, subject self-assessment, and determinations of skin barrier integrity (transepidermal water loss) and stratum corneum protein changes.
Results
The cosmetic regimen significantly improved wrinkle appearance after 8 weeks relative to tretinoin, with comparable benefits after 24 weeks. The cosmetic regimen was significantly better tolerated than tretinoin through 8 weeks by all measures.
Conclusions
An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
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