Regeneration of human bones in hip Osteonecrosis and human cartilage in knee Osteoarthritis with autologous Adipose-tissue-derived stem cells：a case series（2）
The second case concerns a 47-year-old Korean man who had been working as a diver until three years prior to presentation.
Approximately three years prior to presentation, he started having right hip pain and was diagnosed with osteonecrosis of the right hip. His pain had progressed over three years and he was offered a total hip replacement (THR). Being reluctant to proceed with the surgical procedure, he elected to proceed with stem cell treatment. Before the procedure, a repeat MRI of the hip was performed and a diagnosis of osteonecrosis of the femoral head, stage 4, was confirmed.
He then underwent the same procedures as our first patient. After the fourth week of the ADSC injection, his pain improved more than 30% along with improvement in range of motion. However, by week 12, his pain had only minimally improved further (Tables 3 and 4). Interestingly, a repeat MRI taken at week 12 showed a significant filling of bone defects with a possibility of bone matrix formation at the site of necrosis in the femoral head (Figure 2).
Table 3. Functional rating index and visual analog scale (VAS) score of patient 2
Table 4. Physical therapy (PT) range of motion of patient 2
Figure 2. MRI of the right hip; T1 sequential coronal views. The blue arrow shows the pattern of probable bone regeneration. The green arrow shows probable bone consolidation.
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